Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)

Cincinnati Children's Hospital Medical Center

Status

Active, not recruiting

Conditions

Congenital Heart Defects

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT01196182

U01HL098123 (U.S. NIH Grant/Contract)

U01HL098162 (U.S. NIH Grant/Contract)

U01HL098153 (U.S. NIH Grant/Contract)

701

U01HL098163 (U.S. NIH Grant/Contract)

U01HL098188 (U.S. NIH Grant/Contract)

U01HL098147 (U.S. NIH Grant/Contract)

5U01HL098188-03 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Congenital heart defects (CHD) are the most common major human birth malformation, affecting ~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in contributing to the infant mortality rate. Current understanding of the etiology of pediatric cardiovascular disorders is limited.

The Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) is a multi-center, prospective observational cohort study. Participants will be recruited from the Pediatric Cardiac Genomics Consortium's (PCGC) centers of the NHLBI-sponsored Bench to Bassinet (B2B) Program. Biological specimens will be obtained for genetic analyses, and phenotype data will be collected by interview and from medical records. State-of-the-art genomic technologies will be used to identify common genetic causes of CHD and genetic modifiers of clinical outcome.

To accomplish this, the PCGC will develop and maintain a biorepository of specimens (DNA) and genetic data, along with detailed, phenotypic and clinical outcomes data in order to investigate relationships between genetic factors and phenotypic and clinical outcomes in congenital heart disease.

Enrollment

32,000 estimated patients

Sex

All

Ages

Under 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

• Signed consent form

Exclusion criteria