Congenital Heart Diseases and Developmental Assessment in Cholestatic Infants Under Two Years

Assiut University

Status

Not yet enrolling

Conditions

Cholestasis

Congenital Heart Disease

Study type

Observational

Funder types

Other

Identifiers

NCT07247604

CHD-CHOLEST-ASSIUT

Details and patient eligibility

About

Congenital heart diseases (CHDs) are common in infants with cholestasis due to shared prenatal and metabolic factors. This study aims to determine the frequency and types of CHDs and to assess physical and mental development in children below two years with cholestasis at Assiut University Children's Hospital.

Full description

Congenital heart diseases (CHDs) are the most common structural malformations in childhood, affecting approximately 8-12 per 1,000 live births worldwide. Infants with systemic disorders such as neonatal and infantile cholestasis have a higher prevalence of CHDs due to overlapping prenatal insults, genetic syndromes, and metabolic disturbances. Cholestasis, defined as impaired bile flow with conjugated hyperbilirubinemia, may arise from biliary atresia, neonatal hepatitis, or metabolic and syndromic disorders such as Alagille syndrome. Several studies highlight a strong association between cholestasis and CHDs, and early recognition of this dual burden is essential to improve outcomes.

Enrollment

106 estimated patients

Sex

All

Ages

1 month to 2 years old

Volunteers

No Healthy Volunteers

Inclusion criteria