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Congenital Lung Anomalies (CLA) Swiss Database (CLADatabase)

University Hospitals (UH) logo

University Hospitals (UH)

Status

Enrolling

Conditions

Bronchogenic Cancer
Congenital Lung Malformation
Congenital Lung Cyst
Pleuropulmonary Blastoma
Sequestrum
Acinar Dysplasia

Treatments

Procedure: Malformations resection

Study type

Observational

Funder types

Other

Identifiers

NCT03044769
CLA-2016

Details and patient eligibility

About

Congenital lung anomalies include different pathologies such as congenital cystic adenomatoid malformation, pulmonary sequestration, bronchial atresia, emphysema, bronchogenic cyst. They concern less than 1/10000 births and their physiopathological origin is still poorly understood. The main goal of this project is to pool the cases from different swiss centers on a prospective cohort study, first to increase knowledge of clinical and radiological evolution and their correlation with histological data, and second to analyse the pathological embryological mechanism underlying these malformations.

Full description

To register prospectively clinical, biological, radiological and histological datas in a multicentric database (secured internet link, via Secutrial® software). for children with prenatal diagnosis of this kind of malformation. This study is conducted by a multidisciplinary team, involving obstetricians, neonatologists, pneumologists, pediatric surgeons, radiologists and anatomopathologists. To create a tissue biobank

Outcomes:

Contribute to the definition of a standardized procedure at the Swiss level for the treatment of patients suffering from these malformations, Improve the assessment of lesion evolution related to CLA, and Possibly validate some biomarkers, which could help to identify individuals at risk. On the long term, these results could also support the development of innovative therapies targeting the factors involved in lung development.

Enrollment

100 estimated patients

Sex

All

Ages

Under 16 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All patients diagnosed with congenital lung anomalies

Exclusion criteria

  • None

Trial design

100 participants in 2 patient groups

Patient with CLA with surgery
Treatment:
Procedure: Malformations resection
Patient with CLA without surgery

Trial contacts and locations

1

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Central trial contact

Isabelle Andrieu Vidal, MD PhD; Isabelle Ruchonnet-Métrailler, MD PhD

Data sourced from clinicaltrials.gov

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