Congenital Syphilis Prospective Cohort With Retrospective Evaluation

Hospital de Niños R. Gutierrez de Buenos Aires

Status: Completed

Conditions: Syphilis, Congenital

Study type: Observational

Funder types: Other

Identifiers

NCT04137601

SiC cohort

Details and patient eligibility

About

Syphilis is an infectious disease caused by Treponema pallidum. In children, there are two different forms of this disease; acquired syphilis and congenital syphilis, which results from transplacental transmission of spirochetes.

The worldwide incidence of congenital syphilis has increased in past years, probably due to inadequate control of pregnant women and lack of early diagnose and treatment in acute infected adults.

This infection can have numerous and non-specific manifestations at all stages, and may simulate other diseases, which can delay diagnose if not suspected.

A high number of newborns can be asymptomatic, so diagnose is confirmed or discharged by serologic testing after 6 to 10 months of age.

This study will observe the clinical presentation and the laboratory of patients with CS treated.

Enrollment: 62 patients

Sex: All

Ages: Under 1 year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infants with reactive VDRL /RPR of mothers with positive serology without confirmed treatment or incomplete.
• Patients with compatible clinical signs of syphils.

Exclusion criteria

• Patients with diagnosis of acquired syphilis
• Patients whose medical records are missing