Congenital Uterine Anomalies & Pregnancy in Polycystic Ovarian Syndrome (CONUTA&PPCOS)

Bursa Uludag University

Status: Unknown

Conditions: Mullerian Anomaly of Uterus, Nec

Treatments: Diagnostic Test: Ultrasound and Hysterosalpingography

Study type: Observational

Funder types: Other

Identifiers

NCT04776915

2020-18/17

Details and patient eligibility

About

Prospective research in which patients who applied to UUTF Gynecology and Obstetrics ART center for the treatment of infertility (inability to conceive despite one year of unprotected sexual intercourse), who will undergo IVF due to PCOS and unexplained infertility

Full description

As of 01/10/2020, IVF cycles of patients with PCOS (n = 105) and unexplained infertility (n = 105) who have applied to Bursa Uludag University Gynecology and Obstetrics Department, Reproductive Treatments Center, will be included in the study. Demographic data of all patients (age, BMI, smoking), presence of hyperandrogenism findings such as systemic diseases, hirsutism, alopecia, FSH, LH, LH/FSH ratio, estradiol levels, pregestational serum AMH levels, uterine anomalies detected by transvaginal USG or hysterosalpingography, controlled ovarian hyperstimulation protocols and doses; Besides, DHEA-S, Free Testosterone, 17-OH Progesterone levels will be recorded in patients diagnosed with PCOS. All these data are routine laboratory and imaging parameters of patients who underwent in vitro fertilization in our UYTE center. Pregnancy results of the patients (biochemical pregnancy, anembryonic pregnancy, abortion, clinical pregnancy, live birth), perinatal results and complications during clinical pregnancy, delivery ways, and newborn APGAR scores will be recorded. Results will be compared with patients in the control group diagnosed with unexplained infertility.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being in the age range of 20-40
• Need for an assisted reproductive method due to PCOS or unexplained infertility

Exclusion criteria

• <20 years or >40 years
• Detecting a cause for infertility other than PCOS

Trial design

100 participants in 2 patient groups

Study Group

Description:

Infertile patients due to polycystic ovarian syndrome

Treatment:

Diagnostic Test: Ultrasound and Hysterosalpingography

Control Group

Description:

Infertile patients due to unexplained infertility

Treatment:

Diagnostic Test: Ultrasound and Hysterosalpingography