Congestive Heart Failure: Causes of Sudden Worsening

University Hospital Hradec Kralove

Status: Unknown

Conditions: Congestive Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT01081925

MSM0021620817-HKJC

Details and patient eligibility

About

The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.

Full description

Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• able to provide informed consent
• aged 19 years or more
• history of heart failure of at least one month
• examined or hospitalized for acute dyspnea at rest or with minimal exertion
• clinical signs of fluid overload defined as at least one of following:
• rales
• jugular venous distension
• peripheral edema
• pulmonary congestion on X-ray
• NT-proBNP above 210 pmo/l

Exclusion criteria

• none

Trial design

100 participants in 1 patient group

Congestive heart failure

Description:

Patients suffering from sudden worsening of congestive heart failure