Connectome Characterization With Aging (AGE-CONNECT)

Civil Hospices of Lyon

Status: Completed

Conditions: Healthy

Treatments: Other: Single complete MRI intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT03109275

69HCL16_0687

Details and patient eligibility

About

The main aim of this project is to develop a new model to characterize brain connectivity and its changes with aging. This characterization will be based on new sensitive and specific markers, allowing a better understanding of structural and functional brain networks. To this end, two complementary MRI methods will be developed: 1) Resting-state functional MRI (rs-fMRI) which allows the measurement of cerebral activity in different cortical gray matter regions, and 2) high angular resolution diffusion imaging (HARDI) MRI, which allows to characterize brain tissue microarchitecture. HARDI sequences will be developed to acquire and reconstruct fiber tractography of patient's brains. In combination with conventional MRI, both HARDI and rs-fMRI will be used to estimate the connection degree between each pair of cortical regions, so- called "Connectome". Once generated, brain networks will be quantified through numerous graph metrics, such as graph density, global efficiency and assortativity (etc.), reflecting the organization and topology of subjects' connectivity with aging.

Enrollment: 10 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Volunteers (Men and women) aged between 18 and 50 years
• No neurological or psychiatric diseases

Exclusion criteria

• MRI contraindications
• Pregnant women or nursing women
• Persons under guardianship or any other administrative or deprivation of liberty or of right

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Single MRI examination

Active Comparator group

Description:

40 subjects will benefit from a full MRI

Treatment:

Other: Single complete MRI intervention

Reproducibility study

Sham Comparator group

Description:

10 subjects will benefit from the realization of 3 MRI. An MRI examination performed at the time of inclusion and then an examination, at 3 months and at 9 months (ie 3 examinations per subject).

Treatment:

Other: Single complete MRI intervention