Connectomics in Psychiatric Classification of Bipolar Disorder and Schizophrenia

W

Washington University Early Recognition Center

Status

Completed

Conditions

Schizophrenia
Bipolar Disorder

Treatments

Other: no intervention

Study type

Observational

Funder types

Other

Identifiers

NCT02756065
201404123

Details and patient eligibility

About

Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with bipolar disorder and schizophrenia.

Full description

This study extends the assessment of brain connectivity and function, being conducted in the Human Connectome Project (HCP), to psychiatrically ill populations. The HCP consortium has made significant improvements in MRI instrumentation, data acquisition, preprocessing, and analysis. These improvements are currently providing publicly available data on the structure, function, and connectivity of young adult human (age 22-35) brains at unprecedented spatial resolution, temporal resolution, and accuracy. This study will focus on individuals aged 18-40 years who have a diagnosis of either schizophrenia/schizoaffective disorder or bipolar disorder, or are healthy controls. Additionally, similar to the HCP, the investigator will study the effect of genetics on the patterns of brain connectivity in various psychiatric populations. DNA will be collected non-invasively from saliva. Furthermore, this investigator will study cortisol levels in hair samples as an additional assessment to help characterize brain imagining findings.

Enrollment

220 patients

Sex

All

Ages

18 to 30 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Between ages 18-30

Exclusion criteria

  • Head Injury
  • Unstable Medical Condition

Trial design

220 participants in 3 patient groups

Control
Description:
Individuals between 18-30 years old No diagnosis of Bipolar Disorder or Schizophrenia No intervention used
Treatment:
Other: no intervention
Bipolar Disorder
Description:
Individuals between 18-30 years old Diagnosis of Bipolar Disorder No intervention used
Treatment:
Other: no intervention
Schizophrenia
Description:
Individuals between 18-30 years old Diagnosis of Schizophrenia or Schizoaffective Disorder No intervention used
Treatment:
Other: no intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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