Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness

Capital Medical University

Status: Enrolling

Conditions: Consciousness Disorder

Treatments: Drug: Different drug dosage

Study type: Observational

Funder types: Other

Identifiers

NCT05823454

ywn20220929

Details and patient eligibility

About

Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 - 65 years old, native Chinese speaker, dextromanuality;
• Chronic disorder of consciousness;
• Spinal cord electrical stimulator implantation under general anesthesia;
• Signed informed consent.

Exclusion criteria

• Continuous sedation was administered within 72 hours prior to the study;
• Open head injury, parenchymatectomy and other damage of brain structural integrity;
• The intracranial compliance decreased due to hydrocephalus and swelling;
• Known hearing impairment;
• Airway stenosis and various causes of severe ventilation or ventilation dysfunction;
• Known or suspected cardiac dysfunction;
• Allergic to intravenous general anesthetics;
• Associated with other mental or neurological diseases;
• Other reasons are not suitable to participate in this study.

Trial design

200 participants in 5 patient groups

Propofol

Description:

Intravenous infusion

Treatment:

Drug: Different drug dosage

Dexmedetomidine

Description:

Intravenous infusion

Treatment:

Drug: Different drug dosage

Esketamine

Description:

Intravenous infusion

Treatment:

Drug: Different drug dosage

Sevoflurane

Description:

Inhalation anesthesia

Treatment:

Drug: Different drug dosage

Remifentanil

Description:

Intravenous infusion

Treatment:

Drug: Different drug dosage