Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy

Jin Ni

Status and phase: Unknown; Phase 4

Conditions: Emergence Deliruim; Cerebral Palsy

Treatments: Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02244515

ED cerebral palsy

Details and patient eligibility

About

The purpose of this study is to determine whether dexmedetomidine is effective in the treatment of emergence deliruim after sevoflurane anesthesia in children with cerebral palsy.

Enrollment: 80 estimated patients

Sex: All

Ages: 2 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Non-quadriplegic (mono-,di-, hemiplegic) children with CP that are scheduled for elective Achilles-tendon lengthening procedure Guangzhou Women and Children's Medical Center, Guangzhou, China, with American Society of Anesthesiologists (ASA) physical status I or II.

Exclusion criteria

Participants that displayed symptoms of sinus bradycardia and atrio-ventricular block, non-communicative severe developmental delay, seizure disorders, and treatment with seizure medications

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups, including a placebo group

Group C

Placebo Comparator group

Description:

Five minutes prior to the commencement of the surgical procedure, Group D participants were administered 10 ml NaCI 0.9%.

Group D

Experimental group

Description:

Five minutes prior to the commencement of the surgical procedure, Group D participants were administered dexmedetomidine 0.5μg•kg-1 diluted in 10 ml NaCI 0.9%

Treatment:

Drug: dexmedetomidine