Considering alloHCT: Opportunities for Patient Reflection During Decision-Making Via Digital Stories (CHORDS)

University of Rochester

Status: Enrolling

Conditions: Myeloid Malignancy

Treatments: Other: CHORDS

Study type: Interventional

Funder types: Other

Identifiers

NCT07263074

UOCPC25049

Details and patient eligibility

About

This is a two-arm pilot randomized trial that assesses the feasibility and preliminary efficacy of a digital story and values clarification intervention (Considering alloHCT: Opportunities for Patient Reflection During Decision-Making via Digital Stories [CHORDS]) compared to usual care among patients with myeloid cancers considering allogeneic hematopoietic cell transplantation (alloHCT).

Full description

Our proposed intervention is Considering alloHCT: Opportunities for Patient Reflection During Decision-Making via Digital Stories (CHORDS), which includes: 1) real-life digital stories of individuals with similar experiences who previously underwent consultation for allogeneic hematopoietic cell transplantation and their caregivers and 2) explicit values clarification exercises designed to help patients reflect on their emotions and clarify what matters to them, including a) an interactive workbook, and b) best-worst scaling. Together, they help patients reflect on their values and prioritize their own needs and goals, enhance emotional awareness, and gain experiential knowledge from peers to better understand the real-life implications of treatment risks and benefits.

Enrollment: 120 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Patients

Inclusion criteria:

1. Age >21 years old
2. Diagnosis of myeloid cancer (AML, MDS, myelofibrosis, CML, or MDS/MPN)
3. Being considered for alloHCT
4. Able to provide informed consent
5. Able to speak English. The reason for this is because the digital stories have been created in the English language and their multimedia form cannot easily be translated.

Exclusion criteria 1) Patients with psychiatric or cognitive conditions which the hematologist believes prohibits informed consent or compliance with study procedures

Caregivers

Inclusion criteria:

1. Age >18 years old
2. Selected by the patient when asked if there is a "family member, partner, friend or caregiver with whom you discuss or who can be helpful in health-related matters."
3. Caregiver may be paid/professional or informal caregiver
4. Able to provide informed consent
5. Able to speak English

Exclusion Criteria:

1) None

Hematologists

Inclusion criteria:

1) Hematologists of the patients who agree to enroll on the study who are part of Wilmot Cancer Institute.

Exclusion criteria

1) None

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Intervention (CHORDS)

Experimental group

Description:

The CHORDS intervention consists of 1) digital stories created by individuals who previously underwent consultation for alloHCT and 2) explicit values clarification exercises designed to help patients reflect on their emotions and clarify what matters to them, including a) an interactive workbook, and b) best-worst scaling (BWS).

Treatment:

Other: CHORDS

Usual Care

No Intervention group

Description:

Patients randomized to the usual care arm will receive standard of care. Patients (and their caregivers when available) randomized to usual care will not participate in CHORDS. Patients and caregivers will complete baseline (T1) and post-alloHCT office visit (T3, T4, T5) assessments.