Consistency of Electrical Cardiometry and Pulmonary Artery Catheter

Fudan University

Status: Enrolling

Conditions: Right Ventricular Dysfunction; Pulmonary Arterial Hypertension

Treatments: Behavioral: passive leg raising; Drug: dobutamine test; Drug: inhaled nitric oxide

Study type: Interventional

Funder types: Other

Identifiers

NCT05587400

COMEEC

Details and patient eligibility

About

Currently, the gold standard method to estimate CO in patients with PAH or RV dysfunction is pulmonary artery catheter (PAC), however, the invasiveness and complexity of PAC has limited its usefulness in many clinical scenarios. By measuring the thoracic electrical bioimpedance, electrical cardiometry (EC) technique has been reported to noninvasively estimate cardiac output (CO) and other parameters related to cardiac contractility and fluid status in various cardiovascular disorders. However, in patients with pulmonary arterial hypertension (PAH) and/or right ventricular (RV) dysfunction, few study has been reported. The aim of this study is to evaluate the agreement between CO measured by PAC as the referenced method and CO measured by EC technique in patients with PAH and/or RV dysfunction.

Enrollment: 199 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult cardiac surgery patients
• pulmonary artery hypertension and/or right heart dysfunction
• mechanical ventilation

Exclusion criteria

• life threatening arrhythmia
• severe valve regurgitation
• left ventricular ejection fraction less than 30%
• patients with mechanical circulatory support

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

199 participants in 1 patient group

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Experimental group

Treatment:

Behavioral: passive leg raising

Drug: inhaled nitric oxide

Drug: dobutamine test