Constitution of a Clinico-radiological Database and a Biobank for Patients With Lacunar Infarcts (DHU-LAC)

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Lacunar Strokes

Study type: Observational

Funder types: Other

Identifiers

NCT03552926

P150602

Details and patient eligibility

About

The aim of this study is to determine in patients with a recent lacunar strokes (<15 days), the natural history of cognitive disturbances and disability.

Full description

This bi-centric cohort study aims at determining in patients with recent lacunar strokes (<15 days), the main clinical, radiological, or genetic predictive markers of recurrent stroke, cognitive impairment, dementia, depression gait disturbances and disability.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years and above
• History of recent (less than 15 days) neurological deficit related to a small subcortical infarct (evidenced by medical history or physical examination)
• Diagnosis of recent small subcortical infarct on MRI (hyperintensity on diffusion-weighted imaging showing an infarction in the territory of one perforating artery) presumably responsible for the corresponding neurological deficit
• Lesion diameter mess than 20 mm
• Ability to comply with scheduled follow-up and annual neurological evaluation
• Affiliation to the national French health insurance (sécurité sociale)
• Signature of informed consent

Exclusion criteria

• Prior diagnosis of dementia according to DSM IV criteria
• Prior severe disability with Rankin scale ≥ 4
• Serious concomitant systemic disorder that can compromise the follow-up study;
• Leukoencephalopathy of non-vascular origin;
• Severe psychiatric disorder;
• Inability to obtain an informed signed consent from the patient or his/her family;
• Medical contraindication or refusal to undergo cerebral magnetic resonance scanning (MRI).