Construction of a Prediction Model for Metachronous Colorectal Adenoma

Nanjing Medical University

Status: Unknown

Conditions: Metachronous Colorectal Adenoma

Study type: Observational

Funder types: Other

Identifiers

NCT05183438

2021-SR-343

Details and patient eligibility

About

The study aimed to explore the independent risk factors for the metachronous colorectal adenoma after endoscopic resection, and construct the prediction model of metachronous colorectal adenoma, in order to provide theoretical basis for postoperative follow-up time of patients, and allocate limited medical resources.

Full description

A large cohort of eligible patients were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. Demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for metachronous colorectal adenoma. In the derivation cohort, the LASSO regression method was applied to filter variables and multivariate logistic regression analysis was used to identify important predictors.A prediction model was established based on the results of multivariate logistic regression analysis. The predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness.

Enrollment: 30,000 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged ≥18 and ≤75 years old. Patients with complete data on demography and clinicopathology.

Exclusion criteria

• Patients with a history of inflammatory bowel disease, enterophthisis, familial adenomatous polyposis, P-J syndrome and intestinal lymphoma.

Patients with a previous history of colorectal neoplasm. Patients with a history of severe systemic diseases. Lack of complete clinical data for analysis.

Trial design

30,000 participants in 2 patient groups

patients with metachronous colorectal adenomas

patients without metachronous colorectal adenomas