Construction of Gynecological Tumor Organoids

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Not yet enrolling

Conditions: Organoid; Gynecologic Cancer

Treatments: Other: construction of organoids from gynecological tumor

Study type: Observational

Funder types: Other

Identifiers

NCT06155370

K4903 G&O organoids

Details and patient eligibility

About

This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.

Full description

Explore the construction and maintenance of a large-scale queue of gynecological tumor organoids. Beijing Daxiang Technology Co., Ltd. provides corresponding technical support and chip design. Gynecological oncology center provides tumor samples, clinical information, and pathological support, and biological sample library provides technical support, storage space, and quality management.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age of 18 or older, an informed consent form is provided;
2. The preoperative tumor burden assessment and intraoperative researcher team believe that sampling is feasible;
3. Having relevant requirements for sample library storage;
4. Surgical treatment at Peking Union Medical College Hospital.

Exclusion criteria

1. Unable to meet all inclusion criteria;
2. The research team considers any situations or considerations that may hinder normal pathological assessment.

Trial design

200 participants in 6 patient groups

cohort of cervical cancer organoids

Description:

organoids derived from cervical cancer

Treatment:

Other: construction of organoids from gynecological tumor

cohort of endometrial cancer organoids

Description:

organoids derived from endometrial cancer

Treatment:

Other: construction of organoids from gynecological tumor

cohort of ovarian cancer organoids

Description:

organoids derived from ovarian cancer

Treatment:

Other: construction of organoids from gynecological tumor

cohort of vulva cancer organoids

Description:

organoids derived from vulva cancer

Treatment:

Other: construction of organoids from gynecological tumor

cohort of vaginal cancer organoids

Description:

organoids derived from vaginal cancer

Treatment:

Other: construction of organoids from gynecological tumor

cohort of gestational trophoblastic tumor organoids

Description:

organoids derived from gestational trophoblastic tumor

Treatment:

Other: construction of organoids from gynecological tumor