Consumption of Dairy Yogurt Enhanced Immune Function

Yonsei University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Healthy Volunteers

Treatments: Dietary Supplement: Placebo; Dietary Supplement: RG

Study type: Interventional

Funder types: Other

Identifiers

NCT02535663

YF_immune

Details and patient eligibility

About

To investigate the impact of consumption of dairy yogurt with rhamnogalacturonan (RG) in Korean citrus Hallabong peel polysaccharide on Natural Killer (NK) cell activity and circulating cytokine levels.

Full description

A randomized, double-blind, placebo-controlled study was conducted on 120 nondiabetic and nonobese subjects. Over an 8 week period, the test group consumed one pack (150ml) of dairy yogurt with 50mg probiotics and 100mg Korean citrus Hallabong peel polysaccharide (60% RG, 20% mono- and di-saccharide, 5% polyphenol) each day, whereas the placebo group consumed the same product without Korean citrus Hallabong peel polysaccharide. NK cell activities (%) were measured based on the ratios of effector cells (E) (peripheral blood mononuclear cell, PBMC) from each participant to Target cell (T) (K562 cells) as 10:1, 5:1, 2.5:1 or 1.25:1.

Enrollment: 120 patients

Sex: All

Ages: 30 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The levels of white blood cells under 8x10^3/μL
• males and females
• 30-69 years old
• nondiabetic and nonobese subjects
• able to give informed consent

Exclusion criteria

• consumption of any probiotic products within 1 month before screening
• unstable body weight (body-weight change > 2 kg within 3 months before screening)
• diabetes
• history/presence of significant metabolic disease
• pregnancy or breast-feeding
• acute or chronic infection
• liver disease, kidney disease, gastrointestinal disease, or any other acute or chronic disease requiring treatment
• subjects taking any drugs or supplements

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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120 participants in 2 patient groups, including a placebo group

test group

Experimental group

Description:

Dietary Supplement: RG consumed one pack (150ml) of dairy yogurt containing RG (100mg Korean citrus Hallabong peel polysaccharide) per day for 8 weeks

Treatment:

Dietary Supplement: RG

placebo

Placebo Comparator group

Description:

Dietary Supplement: placebo consumed one pack (150ml) of dairy yogurt without RG per day for 8 weeks

Treatment:

Dietary Supplement: Placebo