Consumption of Eggs Rich in Lutein and Omega-3 Fatty Acids on the Macular Pigment (ALGOVUE)

Pasteur Institute of Lille (IPL)

Status: Completed

Conditions: Age-related Macular Degeneration

Treatments: Other: Nutritional study

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01480700

2011-A00364-37

Details and patient eligibility

About

This study is to determine the impact of the consumption of eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae on the plasma levels of these compounds but also on the macular pigment optical density, whose elevation may be beneficial in the prevention of Age-related Macular Degeneration (AMD).

Enrollment: 99 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects (male or female),
• 18 to 55 years
• Having signed the consent form,
• Susceptible to accept the stresses generated by the study,
• Insured.

Exclusion criteria

• Corrected Visual Acuity <8/10th,

• History of cardiovascular disease, specifically coronary heart disease,

• Characterized dyslipidemia

  * Total cholesterol ³ 2.50 g / L, and / or triglycerides ³ 2.00 g / L

• Lipid-lowering treatment,

• Current smoking or person who stopped smoking less than 6 months

• Cataract or cataract surgery,

• Diabetes

• Body Mass Index (BMI)> 30 kg/m2,

• Taking food supplements in the 3 months preceding the start of the study (carotenoids, omega-3 fatty acids, phytosterols),

• Regular consumption in the three months preceding the start of the study products with added phytosterols.

• Regular consumption of high fatty fish or shellfish rich in omega-3 (4x a week or more): salmon, sardines, mackerel, herring, trout, tuna, red mullet, sea bass, bream, farmed turbot, mussels, squid / squid, anchovies.

• Allergy to eggs

• Dieting

• Difference significant weight over the last 3 months (> 3 kg)

• Inability to understand or adhere to the protocol

• Persons deprived of liberty

• People in a position to judicial protection

• Pregnant Women.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

99 participants in 2 patient groups

rich-eggs

Experimental group

Description:

subjects consume 2 eggs rich in lutein/zeaxanthin and DHA per day during 4 months

Treatment:

Other: Nutritional study

standard eggs

Active Comparator group

Description:

subjects consume 2 standard eggs per day

Treatment:

Other: Nutritional study