Consumption of Probiotics on Salivary Bacteria Causing Dental Caries

Sharda University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Dental Caries

Treatments: Other: placebo; Biological: probiotic

Study type: Interventional

Funder types: Other

Identifiers

NCT02752594

D22052015

Details and patient eligibility

About

Dental caries is a multifactorial disease effecting majority of the human population.One of the etiological factor causing dental caries is salivary mutans streptococci. Reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. A non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.

Full description

40 candidates were selected from a pre-determined group and were randomly assigned to two groups. Group A (n=20) was administered probiotic drink and Group B (n=20) was administered placebo for 14 consecutive days. Saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.

Enrollment: 40 patients

Sex: All

Ages: 20 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Decayed Missing Filled Surfaces less than or equal to 6
• Brushes twice daily

Exclusion criteria

• undergoing orthodontic treatment
• topical fluoride therapy in the past 2 yrs
• using sugar free gums

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups, including a placebo group

probiotic

Experimental group

Description:

2 mg of probiotic powder mixed in 10 ml of distilled water

Treatment:

Biological: probiotic

Other: placebo

placebo

Placebo Comparator group

Description:

10 ml of distilled water

Treatment:

Biological: probiotic

Other: placebo