Consumption of Probiotics on Salivary Bacteria Causing Dental Caries

S

Sharda University

Status and phase

Completed
Phase 3
Phase 2

Conditions

Dental Caries

Treatments

Other: placebo
Biological: probiotic

Study type

Interventional

Funder types

Other

Identifiers

NCT02752594
D22052015

Details and patient eligibility

About

Dental caries is a multifactorial disease effecting majority of the human population.One of the etiological factor causing dental caries is salivary mutans streptococci. Reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. A non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.

Full description

40 candidates were selected from a pre-determined group and were randomly assigned to two groups. Group A (n=20) was administered probiotic drink and Group B (n=20) was administered placebo for 14 consecutive days. Saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.

Enrollment

40 patients

Sex

All

Ages

20 to 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Decayed Missing Filled Surfaces less than or equal to 6
  • Brushes twice daily

Exclusion criteria

  • undergoing orthodontic treatment
  • topical fluoride therapy in the past 2 yrs
  • using sugar free gums

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

40 participants in 2 patient groups, including a placebo group

probiotic
Experimental group
Description:
2 mg of probiotic powder mixed in 10 ml of distilled water
Treatment:
Biological: probiotic
Other: placebo
placebo
Placebo Comparator group
Description:
10 ml of distilled water
Treatment:
Biological: probiotic
Other: placebo

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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