Contact Lenses and Infiltrative Keratitis (CLIK)

State University of New York College of Optometry

Status: Completed

Conditions: Keratitis

Treatments: Device: senofilcon A

Study type: Interventional

Funder types: Other

Identifiers

NCT02186431

CLIK_601933

Details and patient eligibility

About

To quantify and compare baseline tear proteins and ocular response in contact lens wearers with a history of corneal infiltrative events, to those without a history of complications. This will be accomplished via measurement of select anti-inflammatory tear proteins before, during and after contact lens wear.

Enrollment: 32 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Soft contact lens wearers
• Healthy (control), or with history of infiltrative keratitis (case)
• Has a wearable pair of glasses
• Refractive error between +8.00 D and -12.00 D, with less than 1.50 D of astigmatism

Exclusion criteria

• Smoker
• Pregnant or nursing
• Systemic disease that would effect tear proteins
• Punctal plugs
• Use of eye drops in the last week

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

history of corneal infiltrative events

Experimental group

Description:

To quantify and compare baseline tear proteins and ocular response in contact lens wearers with a history of corneal infiltrative events

Treatment:

Device: senofilcon A

without a history of corneal infiltrative events

Active Comparator group

Description:

To quantify and compare baseline tear proteins and ocular response in contact lens wearers without a history of corneal infiltrative events.

Treatment:

Device: senofilcon A