Continued Ventilation During Cardiopulmonary Bypass

Medical University of Vienna

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Other: Lung Ventilation; Other: Non-ventilated Group

Study type: Interventional

Funder types: Other

Identifiers

NCT01627756

2894-2008

Details and patient eligibility

About

Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.

Full description

Cardiopulmonary bypass is well known to induce a strong anti-inflammatory response. Studies had been shown that the contact of blood components with artificial surfaces, the surgical trauma, endotoxemia and a reperfusion injury are in part responsible for the seen immunological affect after surgery. The purpose of this study is to test the effect of continued mechanical ventilation during surgery on a blood marker called soluble ST2 in patients sera. Soluble ST2 acts as a decoy receptor of IL-33 and has anti-inflammatory effects. Elevated soluble ST2 concentrations are reported in patients with acute myocardial infarction, sepsis, congestive heart failure and elevates soluble ST2 levels are associated with adverse outcome.

Enrollment: 30 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Written informed consent
• age > 40 and < 80

Exclusion criteria

• treatment with steroids or immunomodulatory interventions during the past four weeks
• signs of an acute infection

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Ventilation Group

Experimental group

Description:

Volume controlled ventilation was done during the whole surgery.

Treatment:

Other: Lung Ventilation

Non-ventilation Group

Active Comparator group

Description:

In the non-ventilated group lungs were collapsed after completion of CPB until after weaning from the extracorporeal circulation.

Treatment:

Other: Non-ventilated Group