Continuous Application of Lisuride in Parkinson's Disease by Subcutaneous Infusion

Axxonis Pharma

Status and phase

Completed

Phase 3

Conditions

Parkinson's Disease

Treatments

Drug: Continuous Subcutaneous Lisuride Infusion

Study type

Interventional

Funder types

Industry

Identifiers

NCT00408915

EudraCT number:

2005-001006-12

CALIPSO

Details and patient eligibility

About

The aim of the study is to evaluate the long-term efficacy, local tolerability and safety of Lisuride applied as subcutaneous infusion compared to placebo in patients with advanced Parkinson's disease with motor fluctuations and "OFF" periods refractory to conventional treatment.

Full description

The current CALIPSO study investigates the efficacy of a continuous lisuride infusion against the optimized previous oral therapy in patients experiencing motor fluctuations with OFF periods and/or strenuous dyskinesias of more than four hours per day.

The controlled core study is scheduled to last six weeks. Within the study the previous oral therapy will either be continued in a capsule/blinded design (while a placebo infusion is going on concurrently) or the oral therapy is substituted by lisuride infusion (while placebo capsules are administered at the same time).

After the controlled core study all patients whose condition has not worsened during the study (meaning those patients of the placebo infusion group as well, who were treated during the core study just as they were before), will be given the chance to continue with the infusion therapy with lisuride in an open extension phase.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Idiopathic Parkinson's disease for at least 3 years (diagnosis based on the UK Brain Bank Criteria)
Presence of motor fluctuations (wearing-off or other "OFF" periods) and / or presence of troublesome dyskinesia, with a total daily minimum of at least 4 hours, despite optimized oral anti-parkinsonian therapy
Stable levodopa intake, i.e. at least four doses of levodopa per day
Stable dosing of all other anti-parkinsonian drugs, such as dopamine agonists, COMT- and MAO-B inhibitors, amantadine, or anticholin-ergics for a minimum of four weeks prior to inclusion.
The following oral dopamine agonist drugs are allowed in this trial: pramipexol up to a total daily dose of 3,15mg, ropinirol up to a total daily dose of 24mg, cabergoline up to a total daily dose of 6mg or combinations Concomitant diseases are stable and well controlled Willingness and ability to comply with all trial requirements Written informed consent

Exclusion criteria

Non-idiopathic Parkinson's disease (e.g. drug-induced or other forms of secondary or atypical parkinsonism such as MSA)
Significant neurological symptoms not accounted for by Parkinson's disease
History or presence of dementia demonstrated by the Mini-mental status examination (MMSE < 24)
Presence of major depression according to DSM IV criteria (≥ 6 months)
History or presence of epilepsy
Presence of dopaminergic psychosis
Unstable severe concomitant diseases (e.g. liver diseases, kidney diseases or clinically relevant cardiac or coronary dysfunction)
Presence of heart valvular fibrosis or indication of significant valvular stenosis / insufficiency on echocardiogram
History of syncope and/or severe or otherwise symptomatic orthostatic hypotension
Present treatment with neuroleptics, including atypical neuroleptics
Treatment with other CNS active drug therapy (e.g. sedatives, hypnotics, anti-depressants, anxiolytics) unless the dose has been stable for at least four weeks prior to the baseline visit
Participation in another trial of an investigational drug within the last 28 days or current participation in another trial of an investigational drug
Clinically significant laboratory abnormalities
Previous neurosurgery for Parkinson's disease
Alcohol or drug abuse in the past three years