Continuous Glucose Monitoring (POC) in the ICU

United States Army Institute of Surgical Research

Status: Terminated

Conditions: Trauma; Burns

Treatments: Device: Continuous Glucose Monitoring

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00464386

H-06-011

Details and patient eligibility

About

The purpose of this study is to prospectively evaluate whether the addition of continuous glucose monitoring to point-of-care (POC) glucometer monitoring improves glucose control.

Full description

Severe burns and traumatic injury can be associated with protracted illness and prolonged ICU course. The beneficial effects of strict serum glucose control in critically ill surgical patients have been demonstrated. Continuous glucose monitors may improve glucose control by providing close to real-time glucose measurements, giving the critical care team the ability to react to trends before hypo- or hyperglycemia is reached. These improvements may decrease the morbidity and mortality associated with severe thermal injury, thereby minimizing hospital stay and recovery. Burned and injured soldiers, airmen, sailors, and marines may return to duty in a more expeditious fashion, or at minimum, enjoy a better quality of life after discharge from the intensive care unit.

Enrollment: 23 patients

Sex: All

Ages: 18 to 72 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• remain 1 week in an ICU
• 18-72 years old
• severe trauma or thermal injury greater than 20% TBSA burn

Exclusion criteria

• cerebral arterial injury
• myocardial infarction
• pre-existing renal failure or liver failure
• history of hypoglycemia
• history or high risk of seizures
• pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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23 participants in 2 patient groups

POC Glucose Testing

No Intervention group

Description:

Hourly blood glucose monitoring with point of care glucometer (i.e., current standard of care).

Continuous Glucose Monitoring

Experimental group

Description:

Continuous arterial glucose monitoring with Guardian sensor + hourly blood glucose monitoring with point of care glucometer (i.e., current standard of care).

Treatment:

Device: Continuous Glucose Monitoring