Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients

Tongji Hospital

Status: Completed

Conditions: Colon Disease

Treatments: Drug: Remimazolam; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT05801757

CIRC

Details and patient eligibility

About

To observe the sedative effect of continuous infusion of remidazolam in elderly patients undergoing colonoscopic polypectomy.

Full description

To observe the sedative effect of continuous infusion of remidazolam in elderly patients undergoing colonoscopic polypectomy, and to screen the optimal dose of remidazolam, in order to provide a more reasonable and safe sedative and analgesic drug regimen for elderly outpatients undergoing colonoscopic polypectomy.

Enrollment: 114 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 60-80 years old;
• ASA Level I - III;
• Operation time: 15min~1h;
• BMI18.0-29.9；

Exclusion criteria

• Emergency surgery;
• Patients with high risk of gastric satiety and reflux aspiration;
• Allergies to benzodiazepines and opioids;
• Those who have taken sedative, analgesic, or antidepressant drugs within 24 hours;
• Abnormal liver and kidney function;
• Previous drug use history;
• Recently participated in other clinical studies;
• Patients who cannot cooperate with communication.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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114 participants in 3 patient groups

Propofol group

Active Comparator group

Description:

propofol 2-3mg/kg/h

Treatment:

Drug: Propofol

R1 group

Experimental group

Description:

remimazolam 0.5mg/kg/h

Treatment:

Drug: Remimazolam

R2 group

Experimental group

Description:

remimazolam 0.75mg/kg/h

Treatment:

Drug: Remimazolam