Continuous Norepinephrine Administration and Blood Pressure Stability During Anesthetic Induction

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Perioperative Hypotension; Blood Pressure

Treatments: Other: Continuous norepinephrine infusion via an infusion pump; Other: Manual bolus norepinephrine administration

Study type: Interventional

Funder types: Other

Identifiers

NCT05997303

2023-101053-BO-ff

Details and patient eligibility

About

This is a randomized trial investigating whether continuous norepinephrine administration via an infusion pump - compared to manual bolus administration - increases blood pressure stability within the first 15 minutes of anesthetic induction in non-cardiac surgery patients.

The secondary endpoints area under a MAP of 65, 60, 50, and 40 mmHg [mmHg × min], cumulative duration of a MAP <65, <60, <50, and <40 mmHg [min], area above a MAP of 100, 110, 120, and 140 mmHg [mmHg min], cumulative duration of a MAP >100, >110, >120, and >140 mmHg [min] and cumulative dose of norepinephrine indexed to body weight [μg/kg] within the first 15 minutes of anesthetic induction will be assessed.

Full description

not provided

Enrollment: 72 patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 45 years
• American Society of Anesthesiologists physical status II-IV
• scheduled for elective major non-cardiac surgery under general anesthesia
• continuous intraarterial blood pressure monitoring using a radial arterial catheter for clinical indications not related to the trial
• sinus rhythm

Exclusion criteria

• Clinical indication to use a continuous norepinephrine infusion via an infusion pump during anesthetic induction
• Need for femoral artery catheterization
• History of intracranial bleedings or aneurysms
• Patients who are incapable of giving consent
• Pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

72 participants in 2 patient groups

Continuous norepinephrine administration

Other group

Description:

continuous norepinephrine infusion via an infusion pump; norepinephrine dose will be at the discretion of the treating anesthesiologists

Treatment:

Other: Continuous norepinephrine infusion via an infusion pump

Manual bolus norepinephrine administration

Other group

Description:

manual bolus norepinephrine administration; norepinephrine dose will be at the discretion of the treating anesthesiologists

Treatment:

Other: Manual bolus norepinephrine administration