Continuous Paravertebral Block on Postoperative Quality of Recovery After Hepatectomy

Cui Xulei

Status: Completed

Conditions: Nerve Block

Treatments: Procedure: Continuous Paravertebral block with ropivacaine; Procedure: Continuous Paravertebral Block with Saline; Drug: Patient-controlled analgesia with morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT03777644

cuixulei7

Details and patient eligibility

About

Moderate to severe postoperative pain often influence patients quality of recovery after hepatectomy. Systemic opioids given with patient-controlled analgesia has been used after hepatectomy in many medical center, but the analgesic effect can be limited and undesirable side effects may bring about negative effects on patients recovery. Regional block has been proved to improve patients postoperative recovery in many kinds of surgeries.

The investigators therefore designed a prospective, randomized, subject and assessor blinded, parallel-group, placebo controlled study to test the hypothesis that continuous right thoracic paravertebral block increase patients quality of recovery score on the 7th postoperative day after hepatectomy in patients receiving i.v. patient-controlled analgesia (PCA) with morphine.

Enrollment: 76 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-70 yrs
• American Society of Anesthesiologists physical statusⅠ-Ⅲ
• Undergo hepatectomy with J-shape subcostal incision
• Informed consent

Exclusion criteria

• A known allergy to the drugs being used
• Coagulopathy, on anticoagulants
• Analgesics intake, history of substance abuse
• Participating in the investigation of another experimental agent
• Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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76 participants in 2 patient groups, including a placebo group

TPVB + PCA

Experimental group

Description:

Continuous Paravertebral block with ropivacaine and Patient-controlled analgesia with morphine

Treatment:

Procedure: Continuous Paravertebral block with ropivacaine

Drug: Patient-controlled analgesia with morphine

placebo TPVB + PCA

Placebo Comparator group

Description:

Continuous Paravertebral Block with Saline and Patient-controlled analgesia with morphine

Treatment:

Procedure: Continuous Paravertebral Block with Saline

Drug: Patient-controlled analgesia with morphine