Continuous Positive Airway Pressure Effect on Air Trapping in Chronic Obstructive Pulmonary Disease Patients (CPAP)

Shamir Medical Center (Assaf-Harofeh)

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: positive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT01507844

86/09

12

Details and patient eligibility

About

Chronic obstructive pulmonary disease is a disease characterized by small airways inflammation and obstruction. The small airways disease produces hyperinflation (air trapping), which increases with exercise. Continuous positive airways pressure may reduce small airways obstruction and therefore air trapping. Pulmonary function tests including lung volumes at rest and and after exercise will be measured. In addition, exercise endurance time before treatment and after treatment will be measured.

Full description

Continuous positive airways pressure which prevent small air ways collapse and may also clear secretions. At first stage the optimal pressure for reducing air trapping will be determined. In addition, all patients will undergo a maximal exercise test. A baseline complete pulmonary function test is performed followed by continuous positive air way pressure at the pre-determined pressure. This will be followed by exercise at 60% of maximal obtained previously.

Enrollment: 24 patients

Sex: All

Ages: 45 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic obstructive lung disease stage 2-3 GOLD
• FRC > 120%

Exclusion criteria

• active ischemic heart disease
• heart failure
• peripheral vascular disease

Trial design

24 participants in 1 patient group

ventilation

Sham Comparator group

Treatment:

Device: positive ventilation