Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis (CRAI-H)

Nanjing University School of Medicine

Status: Unknown

Conditions: Acute Pancreatitis

Treatments: Other: General treatment; Procedure: Continuous regional arterial infusion of low molecular weight heparin in celiac trunk

Study type: Interventional

Funder types: Other

Identifiers

NCT01626911

CRAI-H

Details and patient eligibility

About

Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished).

In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Symptoms and signs of severe acute pancreatitis according to Atlanta criteria
• Within 3 days from the onset of the disease
• Available for interventional treatment(not sensible to radiocontrast agent)

Exclusion criteria

• Pregnant pancreatitis
• Receiving surgery or aspiration before;need of early surgery
• Patients with coagulation disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

CRAI

Experimental group

Description:

CRAI of LMWH in the celiac trunk

Treatment:

Other: General treatment

Procedure: Continuous regional arterial infusion of low molecular weight heparin in celiac trunk

Conservative treatment

Other group

Description:

Conservative treatment without CRAI, control group

Treatment:

Other: General treatment