Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant

The University of Chicago

Status: Withdrawn

Conditions: Chronic Kidney Disease; Acute Kidney Injury; End Stage Kidney Disease; Liver Disease

Treatments: Procedure: Renal replacement therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01619449

IRB #11-0626

Details and patient eligibility

About

To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT

Full description

as above

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 or older and able to sign consent (or surrogate)
• Receiving liver or combined liver-kidney transplant
• eGFR < or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease
• Pre-operative potassium of < or equal to 5.5 mEq/L

Exclusion criteria

• Pre-operative hemoglobin < or equal to 7 g/dL
• Pre-operative weight > or equal to 125 kig

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Renal replacement therapy

Experimental group

Description:

Liver transplant recipients who receive continuous renal replacement therapy intra-operatively.

Treatment:

Procedure: Renal replacement therapy

No CRRT

Active Comparator group

Description:

This arm consists of standard of care without CRRT in the OR for OLT

Treatment:

Procedure: Renal replacement therapy