Continuous Tart Cherry Juice Supplementation With Metabolic Syndrome Participants

University of Hertfordshire

Status: Completed

Conditions: Hypertension; Insulin Resistance; Metabolic Syndrome

Treatments: Dietary Supplement: Montmorency Tart Cherry Juice; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03619941

LMS/PGR/UH/03319

Details and patient eligibility

About

The present study examined the effect of Montmorency tart cherry juice on functional and blood-based cardio-metabolic markers in humans with Metabolic Syndrome. Participants consumed Montmorency tart cherry juice or a placebo beverage continuously for 7 days in a randomised, crossover trial. Outcome variables were measured immediately prior to supplementation and post-supplementation. Furthermore, on the 7th day of supplementation outcome variables were measured pre- and up to 5 hours post-bolus. It was hypothesised that Montmorency tart cherry juice would improve cardio-metabolic markers, particularly fasting insulin and systolic blood pressure. Furthermore, the study aimed to identify the mechanism of action for any effects of Montmorency tart cherry juice on blood pressure.

Enrollment: 12 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Meet 3 of 5 criteria for Metabolic Syndrome based on National Cholesterol Education Program-Adult Treatment Panel III guidelines:

1. Waist Circumference: >102cm (men), >88cm (women)
2. Fasting Serum Triglycerides: ≥1.69 mmol.L-1
3. Fasting High Density Lipoprotein: <1.03 mmol.L-1 (men), <1.29 mmol.L-1 (women)
4. Blood Pressure: ≥130 mmHg SBP or ≥85 mmHg DBP
5. Fasting Plasma Glucose: ≥6.1 mmol.L-1

Exclusion criteria

• Smokers
• Current or previous history of gastrointestinal, cardiovascular, hepatic or renal disease
• Currently diagnosed with diabetes or uncontrolled hypertension (≥160/100 mmHg)
• Allergy to fructose, maltodextrin or specific fruit products
• Currently taking medication (such as steroids, NSAIDs, antibiotics, antihypertensive, hypoglycaemic, lipid-lowering drugs)
• Currently using any nutritional or antioxidant supplement. Heavy alcohol consumption (>14 units per week).

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo

Montmorency Tart Cherry Juice

Experimental group

Treatment:

Dietary Supplement: Montmorency Tart Cherry Juice