Continuous Versus Bolus Infusion of Terlipressin for Portal Hypertension Related Bleeding in Liver Cirrhosis

General Hospital of Northern Theater Command of Chinese People's Liberation Army

Status: Not yet enrolling

Conditions: Portal Hypertension; Liver Cirrhosis; Variceal Hemorrhage; Esophageal and Gastric Varices; Bleeding

Treatments: Drug: Terlipressin

Study type: Interventional

Funder types: Other

Identifiers

NCT03130127

TERLIPRESSIN-LC

Details and patient eligibility

About

Terlipressin is the mainstay drug for the treatment of acute variceal bleeding in liver cirrhosis. According to the drug instructions, intravenous bolus infusion is the standard approach of terlipressin. It remains unclear about whether or not continuous infusion of terlipressin should be considered.

Full description

Although intravenous bolus infusion of terlipressin is the standard approach, continuous infusion of terlipressin is preferred in clinical practice. The present study is a pilot non-randomized controlled trial to explore the feasibility and safety of continuous infusion of terlipressin for the treatment of acute variceal bleeding in liver cirrhosis.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. A diagnosis of liver cirrhosis;
2. Child-Pugh B or C;
3. Acute gastroesophageal variceal bleeding;
4. Written informed consents. -

Exclusion criteria

1. No liver cirrhosis;
2. Child-Pugh class A;
3. Acute upper gastrointestinal bleeding unrelated to varices;
4. Use of somatostatin or octreotide. -

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Continuous infusion of terlipressin

Experimental group

Description:

In our clinical practice, continuous infusion of terlipressin is being employed.

Treatment:

Drug: Terlipressin

Bolus infusion of terlipressin

Active Comparator group

Description:

Traditionally, a bolus infusion of terlipressin is recommended.

Treatment:

Drug: Terlipressin