Continuous Versus Cyclic Oral Contraceptives for Endometriosis

National and Kapodistrian University of Athens

Status and phase: Unknown; Phase 4

Conditions: Dyspareunia; Pelvic Pain; Dysmenorrhea; Endometrioma

Treatments: Drug: Oral contraceptives cyclic; Drug: Oral contraceptives continuous

Study type: Interventional

Funder types: Other

Identifiers

NCT02237131

NV04042013

Details and patient eligibility

About

To evaluate the efficacy of oral contraceptives in a continuous fashion versus the usual cyclic fashion in the recurrence of endometriosis related symptoms and endometriomas following fertility-sparing surgery.

Full description

Oral contraceptives containing 0.03 mg ethinyl estradiol and 3mg drospirenone will be administered. One tablet a day for 21 days followed by 7 days pill free (cyclic fashion) or one tablet a day in a continuous fashion.

Enrollment: 50 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Women of reproductive age with Symptomatic endometriosis following fertility sparing surgery

Exclusion criteria

Contraindications of use of oral contraceptives

Trial design

50 participants in 2 patient groups

Oral contraceptives cyclic

Experimental group

Description:

Oral contraceptives containing 0.03 mg ethinyl estradiol and 3mg drospirenone will be administered. One tablet a day for 21 days followed by 7 days pill free. The regimen will be repeated for the duration of the trial.

Treatment:

Drug: Oral contraceptives continuous

Drug: Oral contraceptives cyclic

Oral contraceptives continuous

Active Comparator group

Description:

Oral contraceptives containing 0.030 mg ethinyl estradiol and 3mg drospirenone will be administered. One tablet a day for the duration of the trial.

Treatment:

Drug: Oral contraceptives continuous

Drug: Oral contraceptives cyclic