Continuous Versus Discontinuous Design of Encircling Lesions During Ablation for Atrial Fibrillation (CDAF)

Institute for Clinical and Experimental Medicine

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Procedure: catheter ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT03332862

G-17-06-22

Details and patient eligibility

About

Acute efficacy of point-by-point radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation are comparable independantly of the ablation strategy (continous versus discontinuous ablation) under the same condition of power delivery.

Full description

The number of pulmonary vein isolation (PVI) therapy for atrial fibrillation (AF) is increasing. Durable PVI is cornerstone for long-term freedom of AF. In one previous study continuous ablation was suggested to be more efficient in durable PVI. However, this hypothesis has not been proven in randomized fashion.

The current study is to confirm whether continuous versus discontinuous design of encircling lesions are comparable under the same conditions of power delivery.

The study design is a two-centre prospective randomized trial to compare the acute efficacy by using the above described approaches.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing pulmonary vein isolation with radiofrequency catheter ablation for paroxysmal atrial fibrillation treatment.

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Discontinuous ablation

Experimental group

Description:

perform discontinuous ablation of ipsilateral pulmunary veins.

Treatment:

Procedure: catheter ablation

Continuous ablation

Active Comparator group

Description:

perform continuous ablation of ipsilateral pulmunary veins.

Treatment:

Procedure: catheter ablation