Continuous Versus Intermittent Administration of Epidural Analgesia During Labor

Mongi Slim Hospital

Status: Completed

Conditions: Epidural; Analgesia

Treatments: Procedure: Continuous epidural infusion; Procedure: PCEA Infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT04826120

Epidural in Labor

Details and patient eligibility

About

prospective randomized single blind study, including full term adult parturients, ASA 2, 3 status, scheduled for vaginal delivery. patients were randomized at 3 cm of cervix dilatation, into 2 groups.

Epidural analgesia was initiated and maintained with a solution of Bupivacaine 0,125% and Sufentanil 0,25 mcg/ml. After an initial bolus of 16 ML, patients were randomly assigned to receive intermittent boluses of 8 ml every 60 minutes after the initial dose followed by supplementary PCEA boluses of 8 ml for the first group ( PCEA group) or a continuous epidural infusion at the rate of 8 ml/h adjustable and starting immediately after The initial bolus of 16 ml for patients of the second group (CEI Group).

Full description

prospective randomized single blind study, including full term adult parturients, ASA 2, 3 status, scheduled for vaginal delivery. patients were randomized at 3 cm of cervix dilatation, into 2 groups.

Epidural analgesia was initiated and maintained with a solution of Bupivacaine 0,125% and Sufentanil 0,25 mcg/ml. After an initial bolus of 16 ML, patients were randomly assigned to receive intermittent boluses of 8 ml every 60 minutes after the initial dose followed by supplementary PCEA boluses of 8 ml for the first group ( PCEA group) or a continuous epidural infusion at the rate of 8 ml/h adjustable and starting immediately after The initial bolus of 16 ml for patients of the second group (CEI Group).

The main outcome of this study was: the incidence of motor Blockage. Our secondary outcomes were: maternal satisfaction, local anaesthetic and sufentanil cumulated doses, duration of the second stage of labor, mode of delivery and pain during labor using the Visual analogic score (VAS score).

Enrollment: 54 patients

Sex: Female

Ages: 17+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Full term parturients scheduled for vaginal delivery

Exclusion criteria

• patients in whom cesarean section delivery was indicated during labor

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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54 participants in 2 patient groups

PCEA group

Active Comparator group

Description:

Patients of this group had intermittent epidural analgesia via PCEA associated to systematic 8 ml boluses every 60 min during the second stage of labor.

Treatment:

Procedure: PCEA Infusion

CEI Group

Experimental group

Description:

Patients of this group had continuous epidural infusion at the rate of 8 ml/h during the second stage of labor.

Treatment:

Procedure: Continuous epidural infusion