Continuous Versus Repetitive Sevoflurane Administration for Preconditioning

University Hospital Schleswig-Holstein (UKSH)

Status and phase: Completed; Phase 4

Conditions: Myocardial Injury

Treatments: Drug: Sevoflurane

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00569816

UKSHCK-Anae07/06

ACA-GmbH-03-7

Details and patient eligibility

About

Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients schedulded to undergo CABG surgery
• Age 18 to 80 years
• Ejection fraction > 40%

Exclusion criteria

• Emergency cases
• Diabetes
• Not able to give informed consent
• Ejection fraction < 40%

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 3 patient groups

Group 1

Active Comparator group

Description:

Propofol as the primary anesthetic

Treatment:

Drug: Sevoflurane

Group 2

Experimental group

Description:

Sevoflurane administered continuously after induction of anesthesia until initiation of cardiopulmonary bypass.

Treatment:

Drug: Sevoflurane

Group 3

Experimental group

Description:

Sevoflurane administered repetitive up to 1 MAC from induction of anesthesia until initiation of cardiopulmonary bypass. Wash in and wash out performed twice.

Treatment:

Drug: Sevoflurane