Contralateral R1 in Amyotrophic Lateral Sclerosis (MOTOBLINK)

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Civil Hospices of Lyon

Status

Enrolling

Conditions

Amyotrophic Lateral Sclerosis

Treatments

Diagnostic Test: blink reflex evaluation

Study type

Observational

Funder types

Other

Identifiers

NCT06206629
69HCL23_1291

Details and patient eligibility

About

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis. Previous studies have shown that different components of the blink reflex, such as the latencies of homo- and contralateral R2 responses can be affected. Studies have found that a contralateral R1 component can appear in neurological diseases with affection of the central nervous system especially upper motor neuron, such as HTLV1 infection. Thus, you aim to determine if a contralateral R1 component could be present in ALS.

Enrollment

120 estimated patients

Sex

All

Ages

18 to 99 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For patients

  • Aged 18 to 99 years old
  • Referred for suspected motor neuromuscular disease
  • Collection of non-opposition

For healthy subjects:

  • Aged 18 to 99 years old
  • Absence of any neurological pathology
  • Collection of non-opposition

Exclusion criteria

  • Previous damage linked to another cause of the cranial nerves
  • Prior brainstem lesions
  • Persons deprived of liberty by a judicial or administrative decision
  • Patient under judicial protection, unable to express consent

Trial design

120 participants in 3 patient groups

ALS patients
Description:
Patients with ALS (Awaji criteria)
Treatment:
Diagnostic Test: blink reflex evaluation
Non-ALS patients
Description:
Patients referred to the neurophysiology unit for a suspicion of ALS du to motor weakness, but in whom the diagnosis is ruled out.
Treatment:
Diagnostic Test: blink reflex evaluation
Healthy volunteers
Description:
Healthy volunteers who will undergo a blink reflex evaluation on ENMG.
Treatment:
Diagnostic Test: blink reflex evaluation

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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