Contrast Echocardiography in Non-ST Elevation Myocardial Infarction

University of Bergen

Status: Completed

Conditions: Non-ST-Elevation Myocardial Infarction

Treatments: Other: Perflutren Lipid Microsphere ultrasound contrast

Study type: Observational

Funder types: Other

Identifiers

NCT01122069

REK237.07 (Other Identifier)

MCE-NSTEMI

Details and patient eligibility

About

In patients with acute myocardial infarction, treatment logistics are primarily defined based upon ST segment shift in the electrocardiogram. While patients with ST elevation (STEMI) are forwarded to immediate coronary angiography and percutaneous coronary intervention, patients without ST elevation (NSTEMI) are initially medically treated and recommended coronary angiography within 48-72 hours.

Early invasive treatment has been found cost-effective in intermediate and high-risk NSTEMI patients and current guidelines recommend use of the Thrombolysis in Myocardial Infarction (TIMI) risk score to identify patients who will benefit from early intervention due to high risk of new infraction and cardiovascular death. However, new research has suggested that TIMI risk score may not always identify patients with severe angiographic disease.

The purpose of this study was to assess if contrast echocardiography could be used to identify NSTEMI patients with angiographically severe disease independent of their TIMI risk score.

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute non-ST elevation myocardial infarction

Exclusion criteria

• hemodynamic unstable
• mechanical prosthetic heart valve
• severly reduced pulmonary function

Trial design

110 participants in 1 patient group

Contrast echocardiography

Description:

110 patients with acute non-ST elevation myocardial infarct were examined with contrast echocardiography prior to coronary angiography.

Treatment:

Other: Perflutren Lipid Microsphere ultrasound contrast