Contrast Enhanced SWI for Carotid Plaque Imaging

H

Hyun Seok Choi, M.D.

Status

Unknown

Conditions

Carotid Plaque Imaging

Treatments

Other: Methods of carotid wall imaging

Study type

Observational

Funder types

Other

Identifiers

NCT02749916
KC15EIMI0104

Details and patient eligibility

About

This study aims to compare image-based characteristics of carotid walls between symptomatic side and the opposite side. The design of this study is phase IV, prospective observational study.

Full description

Atherosclerosis of craniocervical arteries are one of most important causes of stroke. Carotid artery is the most frequent site of atherosclerosis. Recent research in carotid artery covers not only morphology of lumen but also direct visualization of carotid plaque or vessel wall. Vulnerable carotid plaques share pathologic features of intra-plaque inflammation and hemorrhage. There have been reports about post-contrast SWI in the field of vascular imaging. We hypothesized SWI is so sensitive to gadolinium based contrast agent and hemorrhage that contrast-enhanced SWI can visualize vulnerable carotid plaque. The purpose of this study is to investigate gadolinium-enhanced SWI in detection of vulnerable carotid plaque and compare it with MP-RAGE and DANTE T1-SPACE. This can be used to guide proper treatment for stroke.

Enrollment

25 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with acute or recent (within 3months) stroke or TIA
  • 50-99% stenosis of internal carotid artery by NASCET criteria
  • Written informed consent, prior to registration

Exclusion criteria

  • Hemorrhagic stroke
  • Previous history of carotid endarterectomy (CEA), angioplasty, or stenting
  • Contraindication for MR imaging
  • Hypersensitivity to gadolinium based contrast media
  • Pregnant or lactating women
  • Patients under age of 19-year-old
  • Renal condition : eGFR < 60
  • Patients unable and/or unwilling to comply with treatment or study instructions.

Trial design

25 participants in 1 patient group

Patients with acute or recent (within 3months) stroke
Treatment:
Other: Methods of carotid wall imaging

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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