Contrast-enhanced Ultrasound in Patients With Crohn´s Disease and Food Allergy

Friedrich-Alexander-Universität Erlangen-Nürnberg

Status

Completed

Conditions

Food Allergy

Crohn Disease

Treatments

Other: Provocative diet

Other: Mild diet

Study type

Observational

Funder types

Other

Identifiers

NCT05768971

DCEUS_CD_NMA

Details and patient eligibility

About

The purpose of this study is to investigate differences of the bowel wall thickness visible in conventional ultrasound and bowel perfusion using quantitative Contrast-Enhanced Ultrasound in patients with Crohn´s disease in comparison with healthy controls and patients with food allergy.

Full description

After being informed about the study and potential risks, all participants giving written consent will undergo conventional transabdominal ultrasound and Contrast-Enhanced Ultrasound of the bowel wall with measurement of the bowel wall thickness. In addition a continuous video sequence during Contrast-Enhanced Ultrasound is recorded and perfusion kinetics from the video clips are analyzed using a specific quantification software.

Enrollment

48 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age over 18
Endoscopically and histologically confirmed active Crohn´s disease or
Previously proven food allergy (double-blind or single-blind food challenge tests with placebo controls previously before the sonographic examination, increased blood and / or intestinal Immunoglobulin E levels, elevated methylhistamine values under provocation and with reproducible reactions during food challenge procedures) or
Healthy individuals without abdominal complaints

Exclusion criteria