Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke (CUSCAS)

Versailles Hospital

Status: Completed

Conditions: Cerebral Infarction

Treatments: Other: Contrast injection Sonovue®

Study type: Interventional

Funder types: Other

Identifiers

NCT03115242

P14/06_CUSCAS

2014-A01181-46 (Registry Identifier)

Details and patient eligibility

About

This is a biomedical, single-center, and prospective study of a consecutive patients cohort in acute ischemic stroke with carotid plaque.

Full description

The main objective of this study is to evaluate the prevalence of the contrast taking carotid plaques in these acute ischemic strokes.

The secondary objectives are:

• to determine the clinical, sonographic, CT scanner and MRI characteristics of patients in constituted acute cerebral ischemia with carotid atherosclerotic plaque taking contrast to the doppler ultrasound.
• to explore of the plaque contrast enhancement at 6 months (new injection).

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients aged at least 18 years hospitalized with ischemic stroke signs in the carotid territory, objectified on brain MRI with positive DWI.
• Carotid plaque > 2.5 mm thickness in the ipsilateral carotid territory to the AIC, low echogenicity (Type 1, 2, 3, and 4a of the classification Geroulakos) measured by the assessment "GSM" (median gray level).
• Free and informed consent patient or his representative for contrast injection microbubble.
• Affiliated to health insurance.

Exclusion criteria

• Severe cerebral infarction with NIHSS> 25
• No-indications to the contrast medium injection
• Recent myocardial infarction, unstable angina.
• Heart failure stage III / IV New York Heart Association.
• Cardiac shunt left-right, respiratory distress.
• Allergy to albumin or contrast agents.
• Carotid plaques and hyperechoic calcified (however these plaques will be counted to determine their prevalence in acute AIC).
• Carotid dissection

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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35 participants in 1 patient group

Acute ischemic carotid stroke

Experimental group

Description:

Patients hospitalized in the neurovascular intensive care unit for an acute ischemic stroke with a carotid plaque responding to inclusion criteria. These patients receive a contrast injection Sonovue® will be performed during the neck vessels doppler ultrasound.

Treatment:

Other: Contrast injection Sonovue®