Contrast-enhanced vs. B-mode Ultrasound-guided Percutaneous Biopsy of Retroperitoneal Tumors

Iuliu Hatieganu University of Medicine and Pharmacy

Status

Completed

Conditions

Retroperitoneal Neoplasms

Treatments

Procedure: B-mode US-guided percutaneous biopsy

Procedure: CEUS-guided percutaneous biopsy

Study type

Interventional

Funder types

Other

Identifiers

NCT05659433

CEUS-PBRT

Details and patient eligibility

About

Background: Retroperitoneal tumors are typically large and inhomogeneous, with a variable amount of necrosis within the tumor mass which decreases the diagnostic yield of biopsy (false negative or inadequate).

Rationale: Real-time contrast enhancement can highlight the viable tumoral tissue and avoid the necrotic area.

Aims: To compare contrast-enhanced ultrasound (CEUS) guidance and conventional (B-mode) ultrasound (US) guidance in terms of diagnostic yield, need for repeat biopsy, and rate of adverse events.

Methods: A consecutive series of patients with previously documented retroperitoneal tumors and indications for percutaneous biopsy were randomly assigned to benefit from the standard of practice B-mode US-guided biopsy or CEUS-guided biopsy.

The diagnostic accuracy, need for repeat biopsy, and adverse events were noted.

Enrollment

160 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients with retroperitoneal tumors with indication for percutaneous biopsy

Exclusion criteria

Tumors inaccessible for ultrasound guided biopsy
Standard contraindications for biopsy (altered coagulation tests, poor performance status)
Lack of written informed consent