Contrast-free Magnetic Resonance Angiography (MRA) at 3.0 T for Intracranial Aneurysm Detection

S

Shanghai Jiao Tong University School of Medicine

Status

Unknown

Conditions

Intracranial Aneurysms

Treatments

Other: Examination

Study type

Observational

Funder types

Other

Identifiers

NCT01031147
CASC3

Details and patient eligibility

About

The Chinese Cerebral Aneurysms Survey is a continuing prospective study to evaluate the effectiveness of unenhanced, three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) with volume rendering (VR) at 3-T in the detection of intracranial aneurysms.

Full description

Recent years,three-dimensional time-of-flight MRA (3D-TOF-MRA) has become a useful, contrast-free method for observing intracranial vessels and is widely utilized as a screening examination for intracranial aneurysms. The studies available in Medline show mixed results.Some of these studies just included MRI/MRA in the analysis, which have a high rate of false-positives and are unreliable, and some were lack of control (ruptured aneurysm), precise numbers of false-positive results, standard images process and review, or corroborative IADSA in some patients. Furthermore, most previous studies included small sample size with aneurysm detection at 0.5-T or 1.5-T MR. Thus, these results have been inconclusive because of certain pitfalls in these studies. Since 2007, we have conducted a clinical study to objective detection of intracranial aneurysms in our routine diagnostic work-up of intracranial aneurysms by our neuroradiologists using a standard procedure with 3D-TOF-MRA with VR at 3T. The investigators want to establish the quality data to prospectively compare 3D-TOF-MRA with VR at 3T vs 3D-RDSA in the diagnosis of intracranial aneurysms in a largest cohort of patients and test it accuracy in screening for suspected patients

Enrollment

350 estimated patients

Sex

All

Ages

15 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Suspected or known intracranial aneurysms

Exclusion criteria

  • Patient's inability to cooperate
  • Chronic renal failure patients
  • Any patients with a contraindication to MRA examination, such as pacemaker, orbital metallic foreign body, coronary stent, etc.
  • Any patients with a contraindication to DSA examination, such as allergic to contrast medium, etc.

Trial design

350 participants in 1 patient group

Magnetic resonance angiography
Description:
Three-dimensional time-of-flight magnetic resonance angiography(3D-TOF-MRA) was used to detect the intracranial aneurysms in this study
Treatment:
Other: Examination

Trial contacts and locations

1

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Central trial contact

Yong-Dong Li, MD, Ph.D.; Minh-Hua Li, MD, Ph.D.

Data sourced from clinicaltrials.gov

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