Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research (09-PP-06)

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Alzheimer's Disease

Treatments: Other: Actigraphy and video recording signal

Study type: Interventional

Funder types: Other

Identifiers

NCT01049555

09-PP-06

Details and patient eligibility

About

Neuropsychiatric symptoms form part of the clinical picture of Alzheimer's disease (AD) and other dementias. Irrespective of the severity of the disease, the most frequently encountered symptom is apathy. Apathy is increasingly diagnosed in patients with neurological and psychiatric conditions. Apathy is a disorder of motivation, defined as "the direction, intensity and persistence of goal-directed behaviour". Most of the current descriptions acknowledge this point and consider apathy in terms of a lack of goal-directed behaviour, cognition or emotion. The classical neuropsychiatric symptom assessments are subjective structured interview-based, using input from the caregiver and/or the patient. New technologies are likely to provide us with a more objective measure. An example is ambulatory actigraphy, consisting of a piezoelectric accelerometer designed to record arm movement in three dimensions.

The aim of the present study is to assess using actigraphy and video recording signal, AD patients with (n = 15) and without (n = 15) apathy and control subjects (n = 5) during an activity of daily living scenario .

Enrollment: 42 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male or female, > 65 years ;
• Alzheimer's disease according to the NINCDS-ADRDA criteria (McKhann,Drachman et al. 1984) ;
• Mini Mental Test Examination (MMSE) > 20 ;
• no motor anomaly according to UPDRS III (tremblements, rigidité musculaire) ;
• no depression criteria according to DSM IV-R criteria ;
• patient with a cholinergic treatment at dose stable since 3 months ;
• patient with social insurance ;
• signature of informed consent.

Exclusion criteria

• neuropsychologics assessment impossible due to sensorial and disrupt ;
• prescription of psychotrop treatment (hypnotic, anxiolytic, antidepressant, antipsychotic) in the week previous actigraphy recording.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 3 patient groups

Alzheimer and apathy

Other group

Description:

Alzheimer's disease patients with apathy

Treatment:

Other: Actigraphy and video recording signal

alzheimer without disease

Other group

Description:

Alzheimer's disease patients without apathy

Treatment:

Other: Actigraphy and video recording signal

Case control

Other group

Description:

subject without apathy neither Alzheimer's disease

Treatment:

Other: Actigraphy and video recording signal