Contribution of L-Tyrosine to Recovery From Operational Strain on Return From External Operation (USOP)

Direction Centrale du Service de Santé des Armées

Status: Completed

Conditions: Stress, Psychological

Treatments: Device: Photoplethysmography; Behavioral: Psychological questionnaires; Drug: Placebo; Drug: L-Tyrosine 500 Mg; Biological: Blood collection

Study type: Interventional

Funder types: Other

Identifiers

NCT04549194

2019PBMD06

2020-A01658-31 (Other Identifier)

Details and patient eligibility

About

Operational conditions amplify soldier's constraints and stress factors, upsetting individual and collective adaptive landmarks. The soldier's resistance is strained by the high intensity of stressors, by the long duration of exposure and by their cumulative effect.

This may lead to a state of "operational strain" that refers to chronic stress and the allostatic load imposed by operational constraint.

The investigators believe that operational strain could manifest itself by a kind of accelerated aging of the organism due to the increased allostatic load without sufficient resource restoration (neurotransmitter precursors, partial and repeated sleep deprivation, etc.).

This aging mechanism would be reversible after a sufficient period of resource restoration (sleep, physical activity, adapted diet, etc.).

Enrollment: 116 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• From 18 to 65 years of age

Exclusion criteria

• Tyrosine intake within the previous 15 days
• History of neurological or psychiatric disorder
• History of nephrological or endocrine disorder or liver failure
• Hereditary tyrosinemia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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116 participants in 4 patient groups

Tyrosine - External Operation

Experimental group

Description:

1-month L-Tyrosine treatment following 4-month external operation

Treatment:

Device: Photoplethysmography

Behavioral: Psychological questionnaires

Drug: L-Tyrosine 500 Mg

Biological: Blood collection

Placebo - External Operation

Experimental group

Description:

1-month Placebo treatment following 4-month external operation

Treatment:

Device: Photoplethysmography

Behavioral: Psychological questionnaires

Biological: Blood collection

Drug: Placebo

Tyrosine - Rear Base

Experimental group

Description:

1-month L-Tyrosine treatment following 4 months at rear base

Treatment:

Device: Photoplethysmography

Behavioral: Psychological questionnaires

Drug: L-Tyrosine 500 Mg

Biological: Blood collection

Placebo - Rear Base

Experimental group

Description:

1-month Placebo treatment following 4 months at rear base

Treatment:

Device: Photoplethysmography

Behavioral: Psychological questionnaires

Biological: Blood collection

Drug: Placebo