Contributions From the Analysis of Graphs for Identification of Neural Cliques (BRAINGRAPH)

Rennes University Hospital

Status: Completed

Conditions: Epilepsy

Treatments: Device: Electroencephalography; Device: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02305771

2014-A01461-46

35RC14_9849_BRAINGRAPH (Other Identifier)

Details and patient eligibility

About

The aim of the study is to demonstrate that our semantic knowledge (elements of our long-term memory and the process we use them) respond to a graphic organisation and gather together following accurate patterns called cliques (neural networks).

Full description

Electroencephalography (EEG) with very High spatial Resolution (HR) (EEG-HR, 256 electrodes) allows for a better understanding of the global and local activity of the cerebral neocortex.

In 2012, following publications by Claude Berrou and Vincent Gripon's Internet, introducing new principles of coding information based on graphical representations in connectionist networks, we approached this team to test biological plausibility of this theory in vivo with EEG.

The central concept is the mental information, defined as all elements of knowledge acquired by the long-term memory on which the reason can build to try to respond to new problems. According to this new theory, these elements of knowledge called qualia or features should be connected within cliques networks. However, we currently do not have graphs comparing methods to measure a good index of both spatial and topological similarity between graphs with high resolution electroencephalography.

For this new study, we propose to combine the strengths of several existing methods of graph comparison which, on top of this, will be especially adapted to the specific context of the analysis of the graphs in the cerebral cortex.

The skills used are diverse: information theory, mathematics, graph theory, computer science, neuropsychology, signal processing and neurology.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years and older
• Right-handed ;
• French native speaker
• Having given written informed consent

Exclusion criteria

• Presence of any psychiatric, neuropsychological and developmental disorder
• Any uncorrected visual impairment
• Any trouble or delay in learning to read / speak french
• Fully bilingual or multilingual
• Medication, treatment and / or substances that may alter or modify brain functions
• Pregnancy, breast feeding
• Persons under major legal protection and/or deprived of liberty

MRI-related criterions

• Cardiac pacemaker or implanted defibrillator
• Iron-magnetic surgical clips
• Cochlear implant
• Intra-ocular or brain foreign bodies
• Less than 4 weeks-old stents, less than 6 weeks-old osteosynthesis materials
• Claustrophobia

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

Healthy volunteers

Other group

Description:

20 healthy volunteers will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: * Electroencephalography * MRI

Treatment:

Device: MRI

Device: Electroencephalography