Control of Hypertension by Non-Pharmacologic Means

National Institutes of Health (NIH)

Status and phase

Completed

Phase 3

Conditions

Hypertension

Cardiovascular Diseases

Vascular Diseases

Heart Diseases

Treatments

Behavioral: diet, reducing

Behavioral: alcohol restriction

Drug: antihypertensive agents

Behavioral: diet, sodium-restricted

Study type

Interventional

Funder types

NIH

Identifiers

NCT00000498

R01HL024999 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

To determine whether blood pressure could be controlled by nutritional-hygienic, non-pharmacologic means in hypertensives treated with drugs in the Hypertension Detection and Follow-up Trial (HDFP).

Full description

BACKGROUND:

In the 1970s, many studies had been conducted to control blood pressure in individuals maintained at normotensive levels by the use of weight control and sodium restriction without the concomitant use of anti-hypertensives. The associations between weight, sodium and blood pressure had been well established, but data on the relationship of intervention to blood pressure control had been less so.

DESIGN NARRATIVE:

Patients were randomly assigned to one of three groups. The 95 patients in Group I were advised to control weight, reduce sodium intake, modify dietary and alcohol intake and were removed from pharmacologic treatment. The 44 patients in Group II were removed from pharmacologic treatment, with no other intervention. The 48 patients in Group III were continued on pharmacologic treatment, with no other intervention. The primary endpoint was the proportion in Groups I and II with diastolic blood pressure less than or equal to 90 mm Hg in the absence of antihypertensive drugs. Secondary endpoints were average diastolic and systolic pressures.

The study completion date listed in this record was obtained from the CRISP legacy data.

Sex

All

Ages

40 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Men and women with controlled hypertension.