Control of Leukocyte Function

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Beth Israel Lahey Health

Status

Completed

Conditions

Inflammation, Brain

Treatments

Other: No intervention (drugs) will be given. Purpose: collecting blood for in vitro studies

Study type

Observational

Funder types

Other

Identifiers

NCT03027232
2007P000215

Details and patient eligibility

About

The protocol is to draw peripheral blood from healthy volunteers for in vitro studies. The aims of these in vitro studies are to determine the cellular and intracellular mechanisms by which hypertonic saline and ATP release regulate neutrophil and lymphocyte functions.

Full description

The proper regulation of leukocyte function is critical for immune defense and to prevent autoimmune diseases. Many aspects of immune cell regulation are unknown. A better understanding could lead to novel therapeutic approaches to improve immune function in patients suffering from various diseases. The investigators have found that hypertonic conditions regulate leukocyte functions through feedback mechanisms involving ATP release and purinergic receptors. The purpose of the proposed protocol is to obtain access to peripheral blood from healthy volunteers to study these complex regulatory mechanisms in more detail.

Enrollment

100 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • any healthy volunteer

Exclusion criteria

  • pregnancy
  • needing/using drugs
  • inflammatory or infectious complications

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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