Controlled Donors After Circulatory Death and Brain Death: a Multicenter Study of Transfusion, One-year Graft Survival and Mortality. Cohort Study,

Hospital Clinic of Barcelona

Status: Completed

Conditions: Liver Transplant

Study type: Observational

Funder types: Other

Identifiers

NCT04945135

HCB/2019/1160

Details and patient eligibility

About

RBC requirement ein DBD and DCD liver transplants

Full description

Background: Controlled donation after cardiac circulatory death (cDCD) is accepted to expand the donor pool for liver transplantation (LT). However, transfusion requirements and perioperative outcomes should be elucidated. The aims of this multicentre study are to assess the red blood cell (RBC) transfusions, one-year graft and patient survival after LT with cDCD compared to donors after brain dead (DBD).

Methods: 591 LT patients conducted in ten centers during 2019 were reviewed. Thromboelastometry was used to manage coagulation and blood product transfusion in all centres. Normothermic regional perfusion was the standard technique for organ recovery.

Enrollment: 591 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing LT

Exclusion criteria

• acute liver failure

Trial design

591 participants in 1 patient group

liver donors