Controlling Post-extraction Complications of Impacted Mandibular Third Molar

Al-Azhar University

Status: Completed

Conditions: Preventing Postextraction Complication

Treatments: Drug: Methylprednisolone and Hyaluronic acid; Drug: Methylprednisolone; Drug: Normal saline; Drug: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT04816253

Extraction healing

Details and patient eligibility

About

Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated

Full description

Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction

Enrollment: 72 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy patients
• patient has impacted 3rd molar

Exclusion criteria

• medically compromised patients Heavy smoking patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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72 participants in 4 patient groups, including a placebo group

Normal saline

Placebo Comparator group

Description:

Normal saline irrigation after extraction and No drug placed in tooth socket

Treatment:

Drug: Normal saline

Gengigel

Active Comparator group

Description:

Gengigel (Hyaluronic acid) placed after extraction

Treatment:

Drug: Hyaluronic acid

Methylprednisolone

Active Comparator group

Description:

Methylprednisolone will be given intravenous to a patient half an hour before the surgery

Treatment:

Drug: Methylprednisolone

Methylprednisolone and Gengigel

Active Comparator group

Description:

Methylprednisolone will be given intravenous to a patient half an hour before the surgery and Gengigel (Hyaluronic acid) placed after extraction

Treatment:

Drug: Methylprednisolone and Hyaluronic acid