Conventional Collagen Crosslinking in Young Keratoconus (PED-CXL)

Vasan Eye Care Hospital

Status: Completed

Conditions: Keratoconus

Treatments: Radiation: Conventional CXL

Study type: Interventional

Funder types: Other

Identifiers

NCT02008175

PED_CXL

Details and patient eligibility

About

Keratoconus is a chronic progressive non - inflammatory disorder characterised by progressive steepening and thinning of cornea and high myopic astigmatism, accounting for poor visual acuity in such individuals. Keratoconus seems to be more advanced on presentation, in young patients.

The investigators intend to evaluate the effectiveness of conventional collagen cross linking in young patients diagnosed with keratoconus.

Full description

Keratoconus is progressive ectatic corneal disorder characterised by progressive corneal thinning, steep corneal curvatures and usually associated with high irregular myopic astigmatism.

The major problems concerning keratoconus in young patients are;

1. Rapid rates of progression in young keratoconic corneas as compared to adults.
2. Poor biomechanical properties of young corneas.
3. Poor quality of vision, which predisposes to a very poor quality of life.
4. High rates of complications and failure post keratoplasty in young patients.

The investigators intend to evaluate the effectiveness of conventional collagen crosslinking in young patients with keratoconus with regards to keratometric indices and visual acuity.

Enrollment: 21 patients

Sex: All

Ages: 3 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 years and below.
• Patients diagnosed to have keratoconus at presentation and willing for follow - up at regular intervals post treatment.

Exclusion criteria

• Any disease causing abnormal topography other than keratoconus.
• Any ocular condition predisposing towards poor vision (retinal , lens problems)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

Conventional CXL

Experimental group

Description:

Crosslinking was done according to the standard protocol using hypo-osmolar riboflavin to saturate the cornea following epithelial debridement and ultra - violet light of 370nm with energy density of 3 milliwatts/sq.cm with riboflavin and distilled water alternated every 2 minutes was used for the procedure.

Treatment:

Radiation: Conventional CXL