Conventional Fasting Versus Lipid/Carbohydrate Infusion for Coronary Bypass Patients

Cairo University (CU)

Status: Completed

Conditions: Metabolism Disorder

Treatments: Dietary Supplement: Group C; Dietary Supplement: G group; Dietary Supplement: group L

Study type: Interventional

Funder types: Other

Identifiers

NCT03033667

SMOF

Details and patient eligibility

About

Comparative study between conventional fasting versus overnight infusion of lipid or carbohydrate on free fatty acids and insulin in obese patients undergoing elective first time on-pump coronary artery bypass grafting.

Full description

Obese patients scheduled for bypass surgery randomly assigned to three groups:

Group I (Glucose-group): patients received 500 cc of glucose 10% containing 50 g of glucose and providing patients with 200 Kcal with an osmolarity of 556 mosm/L.

Group II (Lipid-group): patients received 100 cc of lipid solution (soybean 30%, medium chain triglycerides 30%,olive oil 25%,fish oil 15% and 20 mg vitamine E) containing 20 g lipid and provides patients with 200 Kcal with an osmolarity of 380 mosm/L.

Group III (Control-group): patients fasted overnight from 11 pm till 9 am except for clear fluids which were allowed till 5 am.

Enrollment: 63 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Adult patients (> 18 years) with American Society of Anesthesia (ASA) class II-III, BMI 30-40, and New York Heart Association (NYHA) functional capacities I-II, undergoing elective on-pump coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB).

All patients were type 1a World Health Organisation (WHO)/Fredrickson classification of primary hyperlipidemias.

Exclusion criteria

• Patients with diabetes mellitus
• Patients on fibrates
• Patients type 1,2b,3,4 and 5 WHO/Fredrickson classification of primary hyperperlipidemias
• Patients with history of allergic reactions to fish, egg yolk containing foods peanut or soy products
• Patients with carbohydrate or fat intolerance

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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63 participants in 3 patient groups

Glucose group (G group)

Experimental group

Description:

patients received 500 cc of glucose 10% that containing 50 g of glucose and provides patients with 200 Kcal with 556 mosmoles/L.

Treatment:

Dietary Supplement: G group

Lipid Group (L group)

Experimental group

Description:

patients received 100 cc of lipid solution (soybean 30%, medium chain triglycerides 30%,olive oil 25%,fish oil 15% and 20 mg vitamine E) containing 20 g lipid and provides patients with 200 Kcal with osmolarity of 380 mosmoles /L.

Treatment:

Dietary Supplement: group L

Control Group (C group)

Experimental group

Description:

patients was fasting overnight from 11 pm till 9 am except for clear fluids that was allowed till 5 am.

Treatment:

Dietary Supplement: Group C